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赛培新增产品文献：人CRP， SODELISA试剂盒
发布时间：2021-10-19 17:57:28
[摘要]目的 探讨烟酸预防老年人冠脉介入术后造影剂肾病（CIN）作用。 方法 选取 2019 年 9 月—2020 年 11 月赣 州市立医院收治的 150 例冠脉介入老年患者作为研究对象， 按照随机数字表法分为 A 组、B 组和 C 组， 每组各 50 例。A 组为空白对照组，B 组予以中剂量（40 mg）烟酸治疗，C 组予以高剂量（80 mg）烟酸治疗。比较三组 CIN 发 生率、肾功能指标、血清 C-反应蛋白（CRP）和超氧化物歧化酶（SOD）水平及不良反应发生情况。 结果 A、B、C 组 CIN 发生率分别为 16.00%（8/50）、4.00%（2/50）、2.00%（1/50），B、C 组 CIN 发生率均低于 A 组，差异有统计学意义 （P＜0.05）。 术后 1、3 d，B、C 组血清肌酐（Scr）、尿素氮（BUN）、尿酸（UA）、CRP 水平低于 A 组，血清 SOD 水平高于 A 组，差异有统计学意义（P＜0.05）；术后 1 d，C 组血清 SCr、CRP 水平低于 B 组，差异有统计学意义（P＜0.05）。 A、 B、C 组不良反应总发生率分别为 4.00%（2/50）、12.00%（6/50）、28.00%（14/50），A 组不良反应总发生率低于 C 组， 差异有统计学意义（P＜0.017）。 结论 老年人在冠脉介入术术前 24 h 至术后 72 h 给予烟酸 40 mg bid 静脉输注可 降低 CIN 发生率，改善介入术后肾功能、炎症因子及氧化应激反应。
[关键词]烟酸；冠脉介入术；造影剂肾病；预防
[中图分类号] R692 [文献标识码] A [文章编号] 1674-4721（2021）7（a）-0158-04
Study on effect of Niacin on prevention of contrast-induced nephropathy in elderly patients after coronary intervention
ZHANG Ke-fei JIANG Ren-gui ZHANG Bi-long Department of Pharmacy, Ganzhou Municipal Hospital, Jiangxi Province, Ganzhou 341000, China [Abstract] Objective To explore the effect of Niacin on prevention of contrast-induced nephropathy (CIN) in elderly patients after coronary intervention. Methods A total of 150 elderly patients with coronary intervention admitted to Ganzhou Municipal Hospital from September 2019 to November 2020 were selected as the research objects and divided into group A, group B and group C according to random number table method, with 50 patients in each group. Group A was the blank control group, group B was treated with medium dose (40 mg) of Niacin, and group C was treated with high dose (80 mg) of Niacin. The incidence of CIN, renal function indexes, serum C-reactive protein (CRP) and superoxide dismutase (SOD) levels and the incidence of adverse events were compared among the three groups. Results The incidence of CIN in group A, B and C was 16.00% (8/50), 4.00% (2/50) and 2.00% (1/50), respectively. The incidence of CIN in group B and C was lower than that in group A, and the differences were statistically significant (P<0.05). On postoperative day 1 and 3, the serum creatinine (SCR), blood urea nitrogen (BUN), uric acid (UA) and CRP levels in groups B and C were lower than those in group A, and the serum SOD level was higher than that in group A, and the differences were statistically significant (P<0.05). On postoperative day 1, serum SCR and CRP levels in group C were lower than those in group B, and the differences were statistically significant (P<0.05). The total incidence of adverse events in group A, B and C was 4.00% (2/50), 12.00% (6/50) and 28.00% (14/50), respectively. The total incidence of adverse reactions in group A was lower than that in group C, and the differences was statistically significant (P<0.017). Conclusion Intravenous infusion of Niacin 40 mg bid 24 h before and 72 h after coronary intervention in the elderly can reduce the incidence of CIN, improve renal function, inflammatory factors and oxidative stress response after coronary intervention. [Key words] Niacin; Percutaneous coronary intervention; Contrast-induced nephropathy; Prevention
烟酸预防老年人冠脉介入术后造影剂肾病作用的研究_张科飞 (1).pdf
