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赛培新增产品文献：人IL-6、VEGF ELISA试剂盒
发布时间：2021-10-19 17:59:57
【摘要】目的: 观察视网膜激光光凝术联合沃丽汀对糖尿病视网膜病变的视力、视网膜局部微循环及血清因子等指标的 影响。方法: 回顾性分析 160 例糖尿病视网膜病变患者的临床资料，按治疗方式不同分为对照组和观察组，每组 80 例。对照 组采用视网膜激光光凝术治疗，实验组在对照组的基础上联合沃丽汀治疗。分别于入组时、治疗 2 个月后检测患者的黄斑区 视网膜厚度( CMT) 、最佳矫正视力( BCVA) 、视网膜局部微循环指标［视网膜中央动脉的收缩期流速峰值( PSV) 、舒张期末期 流速( EDV) 、阻力指数( ＲI) ］、血清白细胞介素-6( IL-6) 、血管内皮生长因子( VEGF) 水平，并采用糖尿病患者生存质量特异性 量表( DSQL) 评估患者生存质量。结果: 观察组的治疗总有效率高于对照组( 92． 31% vs． 82． 18% ，P ＜ 0． 05) ; 治疗后，观察组 CMT、BCVA、ＲI、血清 IL-6 及 VEGF 水平均低于对照组，PSV、EDV 水平均高于对照组( P ＜ 0． 05) ; 观察组并发症总发生率低于 对照组( 6． 73% vs． 21． 78% ，P ＜ 0． 05) ; 观察组糖尿病患者生存质量特异性量表( DSQL) 各维度评分均低于对照组( P ＜ 0． 05) 。 结论: 视网膜激光光凝术联合沃丽汀可改善糖尿病视网膜病变患者的视力和视网膜局部微循环障碍，减轻炎症反应，减少并 发症。
【关键词】糖尿病视网膜病变; 视网膜激光光凝术; 沃丽汀; 视力; 视网膜局部微循环
【中图分类号】Ｒ779． 63; Ｒ587． 2 【文献标志码】AClinical effect of retinal laser photocoagulation combined with Volitin on diabetic retinopathy XIANG Yi-min，DAI Hong-quan ( Department of Ophthalmology，Fuling Central Hospital，Chongqing 408000，China) 【Abstract】Objective: To observe the effects of retinal laser photocoagulation combined with Voritin on the vision，local retinal microcirculation and serum factors of diabetic retinopathy． Methods: 160 patients with diabetic retinopathy were divided into control group and observation group according to different treatment methods，80 cases in each group． The control group was treated with retinal laser photocoagulation，and the experimental group was treated with Voritin on the basis of the control group． The index of macular reti- nal thickness ( CMT) ，best corrected visual acuity ( BCVA) ，retinal microcirculation indexes ［peak systolic velocity( PSV) ，end-dias- tolic velocity( EDV) ，resistance index( ＲI) ］，serum interleukin-6 ( IL-6) ，and vascular endothelial growth factor ( VEGF) levels were measured at the beginning of enrollment and 2 months after treatment，and the quality of life of patients was evaluated by Diabetes Spe- cific Quality of Life Scale ( DSQL) ． Ｒesults: The total effective rate of treatment in the observation group was higher than that in the control group ( 92． 31% vs． 82． 18% ，P ＜ 0． 05) ． After treatment，CMT，BCVA，ＲI，serum IL-6，and VEGF levels in the observation group were lower than those in the control group，and the levels of PSV and EDV were higher than those in the control group ( P ＜ 0. 05) ． The total incidence of complications in the observation group was lower than that in the control group ( 6． 73% vs． 21. 78% ，P ＜ 0． 05) ． The DSQL scores of diabetic patients in the observation group were significantly lower than those in the control group ( P ＜ 0． 05) ． Conclusion: Ｒetinal laser photocoagulation combined with Volitin can improve vision and local retinal microcircula- tion disorders in patients with diabetic retinopathy，reduce inflammation，and reduce complications． 【Key words】Diabetic retinopathy; Ｒetinal laser photocoagulation; Volitin; Vision; Local retinal microcirculation
视网膜激光光凝术联合沃丽汀对糖尿病视网膜病变的临床疗效_向一旻.pdf
