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赛培新增产品文献：人PGE2，MMP-9 ELISA试剂盒
发布时间：2022-04-08 10:48:40
MIPO 技术与髓内钉固定对胫腓骨骨折患者 HSS 评分、 疼痛介质及血清 PINP、MMP-9 水平的影响
何健，甄小伟 ( 合肥市滨湖医院骨科，安徽 合肥 230000) 【摘要】目的: 探究经皮微创接骨板( MIPO) 技术与髓内钉固定对胫腓骨骨折患者美国特种医院( HSS) 评分、疼痛介质 及血清 I 型胶原氨基端延长肽( PINP) 、基质金属蛋白酶-9( MMP-9) 水平的影响。方法: 选取 70 例胫腓骨骨折患者为研究对 象，根据治疗方式不同分为 A 组和 B 组，每组各 35 例。A 组行髓内钉固定; B 组予以 MIPO 技术。对比两组患者手术相关情 况、术后并发症发生率、手术优良率及手术前后不同时间点血清前列腺素 E2( PGE2) 、P 物质( SP) 、PINP 和 MMP-9 水平和 HSS 评分。结果: A 组患者术中出血量多于 B 组，骨折愈合时间短于 B 组，差异均有统计学意义( P ＜ 0． 05) 。术后 1 d，A 组患者 血清 PGE2、SP 水平高于 B 组( P ＜ 0． 05) ; 术后 1 周、6 周、12 周，A 组患者血清 PINP 水平高于 B 组( P ＜ 0． 05) ，MMP-9 水平低 于 B 组( P ＜ 0． 05) 。两组患者术后并发症发生率比较，差异无统计学意义( P ＞ 0． 05) 。术后 3 个月、6 个月，A 组患者 HSS 评 分高于 B 组( P ＜ 0． 05) ; A 组患者手术优良率高于 B 组( P ＜ 0． 05) 。结论: MIPO 技术、髓内钉固定对胫腓骨骨折患者均可取 得一定效果，MIPO 技术术中出血少，可有效减少疼痛介质释放，而髓内钉固定可促进骨折愈合，调节血清 PINP、MMP-9 水平， 改善患者关节功能，效果更为显著。 【关键词】胫腓骨骨折; MIPO 技术; 髓内钉固定; HSS 评分; 疼痛介质; PINP; MMP-9 【中图分类号】Ｒ687． 3 【文献标志码】A
Effects of MIPO technique and intramedullary nail fixation on HSS score， pain mediators，serum PINP and MMP-9 levels in patients with tibia and fibula fractures HE Jian，ZHEN Xiao-wei ( Department of Orthopedics，Hefei Binhu Hospital，Hefei 230000，Anhui，China) 【Abstract】Objective: To explore the effects of minimally invasive plate osteosynthesis ( MIPO) technique and intramedullary nail fixation on the American Hospital for Special Surgery ( HSS) score，pain mediators and serum procollagen type 1 N-terminal propeptide( PINP) and matrix metalloproteinase-9( MMP-9) levels of patients with tibia and fibula fractures． Methods: 70 patients with tibia and fibula fractures were selected as the research objects，and they were divided into groups A and B according to the different treatment method，with 35 cases in each group． Group A received intramedullary nail fixation，and group B received MIPO technique． Theoperation-related conditions，the incidence of postoperative complications，and the excellent and good rate of surgery，serum prosta- glandin E2 ( PGE2) ，substance P ( SP) levels，serum PINP，MMP-9 levels，and HSS scores at different time points before and after the operation were statistically compared between the two groups． Ｒesults: The intraoperative blood loss of group A was more than that of group B，and the fracture healing time of group A was shorter than that of group B ( P ＜ 0． 05) ． 1 day after operation，the levels of PGE2 and SP in group A were higher than those in group B ( P ＜ 0． 05) ． At 1 w，6 w and 12 w after operation，the level of PINP in group A was higher than that in group B，and the level of MMP-9 in group A was lower than that in group B ( P ＜ 0． 05) ． There was no signifi- cant difference in the incidence of postoperative complications between the two groups ( P ＞ 0． 05) ． At 3 m and 6 m after operation，the HSS score of group A was higher than that of group B ( P ＜ 0． 05) ． The excellent and good rate of group A was higher than that of group B ( P ＜ 0． 05) ． Conclusion: MIPO technique and intramedullary nail fixation can achieve certain results in patients with tibia and fibu- la fractures． MIPO technique has less bleeding during the operation and can effectively reduce the release of pain media，and intramed- ullary nail fixation can promote fracture healing，adjust serum PINP and MMP-9 levels，and improve joint function of patients with more significant effects． 【Key words】Tibia and fibula fractures; MIPO technique; Intramedullary nail fixation; HSS score; Pain mediators; PINP; MMP-9
MIPO技术与髓内钉固定对胫腓骨骨折患者HSS评分、疼痛介质及血清PINP、MMP-9水平的影响.pdf
