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赛培新增产品文献：人sCD40L、sP-sel ELISA试剂盒
发布时间：2022-04-08 12:08:43
心肌缺血时间对急性心肌梗死患者 PCI 术后血清 sCD40L、sP-sel 及心肌重构的影响
韩培天，杜彬彬，张津宁，李文慧 基金项目: 河北省张家口市科学技术研究与发展计划项目( 1821032D) 作者单位: 075100 张家口，河北北方学院附属第二医院心内科 通信作者: 李文慧，E-mail: 27241422@ qq． com 【摘 要】 目的 探讨心肌缺血时间对急性心肌梗死( AMI) 患者 PCI 术后血清可溶性白细胞分化抗原配体 ( sCD40L) 、可溶性 P 选择素( sP-sel) 及心肌重构的影响。方法 选择 2018 年 5 月—2020 年 1 月河北北方学院附属第 二医院心内科成功行急诊 PCI 的 AMI 患者 120 例，依据患者心肌总缺血时间( TTT) 分为早期再灌注组( TTT ＜ 6 h，观 察组) 52 例及晚期再灌注组( TTT≥6 h，对照组) 68 例。比较 2 组患者治疗前后心肌重构指标、血清 sCD40L、sP-sel 水 平、血管内皮功能、氧化应激、炎性因子水平变化。结果 观察组治疗总有效率高于对照组( 94． 23% vs． 67． 65% ， χ2 /P = 12． 626 /0． 000) 。与治疗前比较，2 组患者治疗后血清 NO、血管内皮依赖性舒张功能( FMD) 、GSH、SOD 水平均 明显升高，血清 sCD40L、sP-sel、IL-6、CRP、TNF-α 水平下降，且观察组上述指标改善优于对照组( t /P = 7． 712 / ＜ 0． 001，3． 323 /0． 001，7． 646 / ＜ 0． 001，3． 795 / ＜ 0． 001，22． 371 / ＜ 0． 001，14． 304 / ＜ 0． 001，10． 341 / ＜ 0． 001，37． 163 / ＜ 0． 001，16． 718 / ＜ 0． 001) 。治疗后，2 组 LVEDD 及 LVESD 值均有一定程度降低，LVEF 一定程度升高，但差异无统计 学意义( P ＞ 0． 05) 。结论 经皮冠状动脉介入手术治疗急性心肌梗死患者，早期再灌注较晚期再灌注可更有效降低 血清 sCD40L、sP-sel 水平，减轻炎性反应和氧化应激反应。 【关键词】 急性心肌梗死; 可溶性白细胞分化抗原配体; 可溶性 P 选择素; 心肌重构 【中图分类号】 R542． 2 + 2 【文献标识码】 A
Effects of myocardial ischemia time on serum sCD40L，sP-sel and myocardial remodeling in patients with acute myo- cardial infarction after PCI Han Peitian，Du Binbin，Zhang Jinning，Li Wenhui． Department of Cardiology，the Second Affiliated Hospital of Hebei North University，Hebei Province，Zhangjiakou 075100，China Corresponding author: Li Wenhui，E-mail: 27241422@ qq． com Funding program: Zhangjiakou Science and Technology Research and Development Program ( 1821032D) 【Abstract】 Objective To investigate the effect of myocardial ischemia time on serum soluble leukocyte differentiation antigen ligand (sCD40L), soluble P-selectin (sP-sel) and myocardial remodeling in patients with acute myocardial infarction (AM I). Methods From M ay 2018 to January 2020, 120 patients with AM I who successfully underwent emergency PCI in the Department of Cardiology of the Second Affiliated Hospital of Hebei Northern University were selected and divided into early reperfusion group (TTT < 6 h, Observation group,n = 52 ) and late reperfusion group (TTT ≥6 h, control group,n = 68). The changes of myocardial remodeling indexes, serum sCD40L, sP-sel levels, vascular endothelial function, oxidative stress and inflammatory factor levels were compared between the two groups before and after treatment. Results The total effective rate of the observation group was higher than that of the control group (94.23% vs. 67.65% , χ2 /P = 12.626/0. 000). Compared with before treatment, serum NO, vascular endothelial-dependent diastolic function (FMD), GSH, SOD levels in the two groups were significantly increased after treatment, and serum sCD40L, sP-sel, IL-6, CRP, and TNF-α levels decreased. The improvement of the above indicators was significantly better than that of the control group (t/P = 7.712/ < 0.001, 3.323/0.001, 7.646/ < 0.001, 3.795/0.000, 22.371/ < 0.001, 14.304/ < 0.001, 10.341/ < 0.001, 37.163/ < 0.001, 16.718/ < 0. 001). After treatment, LVEDD and LVESD values in both groups decreased to a certain extent, and LVEF increased to a certain extent, but the difference was not statistically significant (P > 0.05). Conclusion In patients with acute myocardial infarction treated by percutaneous coronary intervention, early reperfusion can more effectively reduce serum sCD40L and sPsel levels, as well as reduce inflammation and oxidative stress than late reperfusion.
心肌缺血时间对急性心肌梗死...P-sel及心肌重构的影响_韩培天.pdf
